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L1CAM Antibody

CAT: 0800-V2182-20UGSize: 20 µgDry Ice: NoHazardous: No
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CAT#:0800-V2182-20UGSize:20 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
This antibody recognizes a cell surface protein of 220-240kDa, identified as L1CAM (L1 cell adhesion molecule) . The L1CAM gene, which is located in Xq28, is involved in three distinct conditions: 1) HSAS (hydrocephalus-stenosis of the aqueduct of Sylvius) ; 2) MASA (mental retardation, aphasia, shuffling gait, and adducted thumbs) ; and 3) SPG1 (spastic paraplegia) . L1CAM also plays an important role in axon growth, fasciculation, and neural migration as well as in mediating neuronal differentiation. Expression of L1 protein is restricted to tissues arising from neuroectoderm. antibody to L1CAM is useful in the identification of primitive neuroectodermal tumors. The antibody binds to tumors of neuroectodermal and glial origin e.g. neuroblastoma and Schwannomas. It does not bind to pediatric or adult brain.
CAS Number
9007-83-4
Specifications
ELISA (order BSA/sodium azide-free format for coating)
UniProt
P32004
Host
Mouse
Reactivity
Human
Immunogen
A homogenous suspension of 16 week human fetal brain was used as the immunogen for this L1CAM antibody.
Clonality
Monoclonal
Isotype
IgG1 k
Clone
UJ127
Applications
ELISA
Purity
Protein G affinity chromatography
Format
Purified
Buffer
1X PBS, pH 7.4
Reconstitution
Store the L1CAM antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This L1CAM antibody is available for research use only.
Storage Conditions
Store the L1CAM antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05% sodium azide
Applications Notes
The concentration stated for each application is a general starting point. Variations in protocols, secondaries and substrates may require the antibody to be titered up or down for optimal performance.
Location
Cell surface
Image Legend
SDS-PAGE Analysis of Purified, BSA-Free L1CAM Antibody (clone UJ127) . Confirmation of Integrity and Purity of the Antibody.

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