Egf receptor Antibody

CAT: 0800-RQ6913Size: 100 µgDry Ice: NoHazardous: No

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CAT#:0800-RQ6913Size:100 µg

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Description

The epidermal growth factor receptor (EGFR; ErbB-1; HER1 in humans) is a transmembrane protein that is a receptor for members of the epidermal growth factor family (EGF family) of extracellular protein ligands. It is mapped to 11 A2; 11 9.41 cM. The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Mutations in this gene are associated with lung cancer.

CAS Number

9007-83-4

Specifications

Western blot: 0.5-1 µg/mL, Immunohistochemistry: 1-2 µg/mL

UniProt

Q01279

Host

Rabbit

Reactivity

Mouse, Rat

Immunogen

Recombinant mouse protein (amino acids L25-P596) was used as the immunogen for the Egf receptor antibody.

Clonality

Polyclonal

Isotype

IgG

Applications

WB, IHC-P

Purity

Affinity purified

Format

Antigen affinity purified

Buffer

Lyophilized from 1X PBS with 2% Trehalose and 0.025% sodium azide

Reconstitution

After reconstitution, the Egf receptor antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Limitations

This Egf receptor antibody is available for research use only.

Storage Conditions

After reconstitution, the Egf receptor antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Formulation

0.5 mg/mL if reconstituted with 0.2ml sterile DI water

Applications Notes

Optimal dilution of the Egf receptor antibody should be determined by the researcher.

Image Legend

IHC staining of FFPE mouse liver with Egf receptor antibody. HIER: boil tissue sections in pH8 EDTA for 20 min and allow to cool before testing.

UniProtKB · Q01279

Epidermal growth factor receptor

EGFR_MOUSE · Mus musculus

View on UniProt ↗

Primary accession: Q01279
Review status: UniProtKB reviewed (Swiss-Prot)
Gene: Egfr
Protein existence: 1: Evidence at protein level
Organism: Mus musculus (Mouse)
Taxonomy ID: 10090
Alternative names: —
EC number: 2.7.10.1
Processing: Precursor
Secondary accessions: —

Protein keywords

Ligand

ATP-bindingNucleotide-binding

Cellular component

Cell membraneEndoplasmic reticulumEndosomeGolgi apparatusMembraneNucleus

Molecular function

Developmental proteinKinaseReceptorTransferaseTyrosine-protein kinase

PTM

Disulfide bondGlycoproteinHydroxylationIsopeptide bondLipoproteinMethylationPalmitatePhosphoproteinUbl conjugation

Technical term

Reference proteome

Domain

RepeatSignalTransmembraneTransmembrane helix

Product Datasheet

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