FOXL2 Antibody

CAT: 0800-RQ6867Size: 100 µgDry Ice: NoHazardous: No
CAT#:0800-RQ6867Size:100 µg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
The forkhead transcription factor gene, FOXL2 located in blepharophimosis, ptosis and epicanthus inversus syndrome (BPES) critical region on chromosome 3q23. Consistent with an involvement in BPES, FOXL2 is selectively expressed in the mesenchyme of developing mouse eyelids and in adult ovarian follicles; in adult humans, it appears predominantly in the ovary. FOXL2 haploinsufficiency may cause BPES types I and II by the effect of a null allele and a hypomorphic allele, respectively. Furthermore, in a fraction of the BPES patients the genetic defect does not reside within the coding region of the FOXL2 gene and may be caused by a position effect. FOXL2 mutations can also cause gonadal dysgenesis or premature ovarian failure (POF) in women, as well as eyelid/forehead dysmorphology in both sexes.
CAS Number
9007-83-4
Specifications
Western blot: 1-2 µg/mL, Immunohistochemistry (FFPE) : 2-5 µg/mL, Flow cytometry: 1-3ug/million cells
UniProt
P58012
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Amino acids ACARQPELAMMHCSYWDHD from the human protein were used as the immunogen for the FOXL2 antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB, IHC-P, FACS
Purity
Antigen affinity purified
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2% Trehalose
Reconstitution
After reconstitution, the FOXL2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This FOXL2 antibody is available for research use only.
Storage Conditions
After reconstitution, the FOXL2 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
Optimal dilution of the FOXL2 antibody should be determined by the researcher.
Location
Nuclear
Image Legend
IHC staining of FFPE mouse ovary tissue with FOXL2 antibody. HIER: boil tissue sections in pH8 EDTA for 20 min and allow to cool before testing.

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