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GIT2 Antibody / GRK-interacting protein 2

CAT: 0800-RQ6715Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-RQ6715Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
ARF GTPase-activating protein GIT2 is an enzyme that in humans is encoded by the GIT2 gene. This gene encodes a member of the GIT protein family, which interact with G protein-coupled receptor kinases and possess ADP-ribosylation factor (ARF) GTPase-activating protein (GAP) activity. GIT proteins traffic between cytoplasmic complexes, focal adhesions, and the cell periphery, and interact with Pak interacting exchange factor beta (PIX) to form large oligomeric complexes that transiently recruit other proteins. GIT proteins regulate cytoskeletal dynamics and participate in receptor internalization and membrane trafficking. This gene has been shown to repress lamellipodial extension and focal adhesion turnover, and is thought to regulate cell motility. This gene undergoes extensive alternative splicing to generate multiple isoforms, but the full-length nature of some of these variants has not been determined. The various isoforms have functional differences, with respect to ARF GAP activity and to G protein-coupled receptor kinase 2 binding.
CAS Number
9007-83-4
Specifications
Western blot: 1-2 µg/mL, Flow cytometry: 1-3ug/million cells, Direct ELISA: 0.1-0.5 µg/mL
UniProt
Q14161
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
Recombinant human protein (amino acids D400-S556) was used as the immunogen for the GIT2 antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB, FACS, Direct ELISA
Purity
Antigen affinity purified
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2% Trehalose
Reconstitution
After reconstitution, the GIT2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This GIT2 antibody is available for research use only.
Storage Conditions
After reconstitution, the GIT2 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
Optimal dilution of the GIT2 antibody should be determined by the researcher.
Image Legend
Flow cytometry testing of human PC-3 cells with GIT2 antibody at 1ug/million cells (blocked with goat sera) ; Red=cells alone, Green=isotype control, Blue= GIT2 antibody.

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Alternative Products

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127319-BiotinGIT2 (ARF GTPase-activating Protein GIT2, ARF GAP GIT2, Cool-interacting Tyrosine-phosphorylated Protein 2, CAT-2, CAT2, G-Protein-coupled Receptor Kinase-interactor 2, GRK-interacting Protein 2, KIAA0148) (Biotin)
MBS6379801-01GIT2 (ARF GTPase-activating Protein GIT2, ARF GAP GIT2, Cool-interacting Tyrosine-phosphorylated Protein 2, CAT-2, CAT2, G-Protein-coupled Receptor Kinase-interactor 2, GRK-interacting Protein 2, KIAA0148) (PE)
MBS6152680-01GIT2 (ARF GTPase-activating Protein GIT2, ARF GAP GIT2, Cool-interacting Tyrosine-phosphorylated Protein 2, CAT-2, CAT2, G-Protein-coupled Receptor Kinase-interactor 2, GRK-interacting Protein 2, KIAA0148) (HRP)
MBS6147377-01GIT2 (ARF GTPase-activating Protein GIT2, ARF GAP GIT2, Cool-interacting Tyrosine-phosphorylated Protein 2, CAT-2, CAT2, G-Protein-coupled Receptor Kinase-interactor 2, GRK-interacting Protein 2, KIAA0148) (FITC)
127319-APCGIT2 (ARF GTPase-activating Protein GIT2, ARF GAP GIT2, Cool-interacting Tyrosine-phosphorylated Protein 2, CAT-2, CAT2, G-Protein-coupled Receptor Kinase-interactor 2, GRK-interacting Protein 2, KIAA0148) (APC)
MBS6379792-01GIT2 (ARF GTPase-activating Protein GIT2, ARF GAP GIT2, Cool-interacting Tyrosine-phosphorylated Protein 2, CAT-2, CAT2, G-Protein-coupled Receptor Kinase-interactor 2, GRK-interacting Protein 2, KIAA0148) APC
MBS6379791-01GIT2 (ARF GTPase-activating Protein GIT2, ARF GAP GIT2, Cool-interacting Tyrosine-phosphorylated Protein 2, CAT-2, CAT2, G-Protein-coupled Receptor Kinase-interactor 2, GRK-interacting Protein 2, KIAA0148) (AP)

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