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HCAM Antibody / CD44

CAT: 0800-RQ6270Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-RQ6270Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CD44 is also known as HCAM, LHR and MC56. The protein encoded by this gene is a cell-surface glycoprotein involved in cell-cell interactions, cell adhesion and migration. It is a receptor for hyaluronic acid (HA) and can also interact with other ligands, such as osteopontin, collagens, and matrix metalloproteinases (MMPs) . This protein participates in a wide variety of cellular functions including lymphocyte activation, recirculation and homing, hematopoiesis, and tumor metastasis. Transcripts for this gene undergo complex alternative splicing that results in many functionally distinct isoforms, however, the full length nature of some of these variants has not been determined. Alternative splicing is the basis for the structural and functional diversity of this protein, and may be related to tumor metastasis.
CAS Number
9007-83-4
Specifications
Western blot: 1-2 µg/mL, Immunofluorescence: 5 µg/mL, Flow cytometry: 1-3ug/million cells
UniProt
P16070
Host
Mouse
Reactivity
Human, Rat
Immunogen
Amino acids RFAGVFHVEKNGRYSISRTEAADLCKAF from the human protein were used as the immunogen for the HCAM antibody.
Clonality
Monoclonal
Isotype
IgG2b
Clone
7H7
Applications
WB, IF, FACS
Purity
Affinity purified
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2% Trehalose
Reconstitution
After reconstitution, the HCAM antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This HCAM antibody is available for research use only.
Storage Conditions
After reconstitution, the HCAM antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
Optimal dilution of the HCAM antibody should be determined by the researcher.
Location
Cell membrane, cytoplasm
Image Legend
Immunofluorescent staining of FFPE human A431 cells with HCAM antibody (green) and DAPI nuclear stain (blue) . HIER: steam section in pH6 citrate buffer for 20 min.

UniProtKB · P16070

CD44 antigen

CD44_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P16070
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
CD44
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
Precursor
Secondary accessions
A5YRN9, B6EAT9, D3DR12, D3DR13, O95370, P22511, Q04858, Q13419, Q13957, Q13958, Q13959, Q13960, Q13961, Q13967, Q13968, Q13980, Q15861, Q16064, Q16065, Q16066, Q16208, Q16522, Q86T72, Q86Z27, Q8N694, Q92493, Q96J24, Q9H5A5, Q9UC28, Q9UC29, Q9UC30, Q9UCB0, Q9UJ36
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Molecular function

Blood group antigenReceptor

Biological process

Cell adhesion

Cellular component

Cell membraneCell projectionMembraneSecreted

PTM

Disulfide bondGlycoproteinPhosphoproteinProteoglycan

Domain

SignalTransmembraneTransmembrane helix

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