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METTL1 Antibody

CAT: 0800-RQ6196Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-RQ6196Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
TRNA (guanine-N (7) -) -methyltransferase is an enzyme that in humans is encoded by the METTL1 gene. This gene is similar in sequence to the S. cerevisiae YDL201w gene. The gene product contains a conserved S-adenosylmethionine-binding motif and is inactivated by phosphorylation. Alternative splice variants encoding different protein isoforms have been described for this gene. A pseudogene has been identified on chromosome X.
CAS Number
9007-83-4
Specifications
Western blot: 1-2 µg/mL, Immunohistochemistry (FFPE) : 2-5 µg/mL, Immunofluorescence: 5 µg/mL, Direct ELISA: 0.1-0.5 µg/mL
UniProt
Q9UBP6
Host
Rabbit
Reactivity
Human, Rat
Immunogen
A human recombinant partial protein (amino acids A2-H276) was used as the immunogen for the METTL1 antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB, IHC-P, IF, Direct ELISA
Purity
Affinity purified
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2% Trehalose
Reconstitution
After reconstitution, the METTL1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This METTL1 antibody is available for research use only.
Storage Conditions
After reconstitution, the METTL1 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
Optimal dilution of the METTL1 antibody should be determined by the researcher.
Location
Nuclear
Image Legend
IHC staining of FFPE human breast cancer with METTL1 antibody. HIER: boil tissue sections in pH8 EDTA for 20 min and allow to cool before testing.

UniProtKB · Q9UBP6

tRNA (guanine-N(7)-)-methyltransferase

TRMB_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q9UBP6
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
METTL1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
2.1.1.33
Processing
—
Secondary accessions
B2RBX1, H7BXF2, Q14105, Q53FS9
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

PTM

AcetylationPhosphoprotein

Coding sequence diversity

Alternative splicing

Molecular function

MethyltransferaseRNA-bindingTransferasetRNA-binding

Cellular component

Nucleus

Ligand

S-adenosyl-L-methionine

Biological process

tRNA processing
Product Datasheet
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