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Fadd Antibody

CAT: 0800-RQ6175Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-RQ6175Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
FADD, Fas-Associated protein with Death Domain, is a universal adaptor protein in apoptosis that mediates signaling of all known death domain-containing members of the TNF receptor superfamily. The FADD gene contains 2 exons and spans approximately 3.6 kb. By analysis of somatic cell hybrid panels and by fluorescence in situ hybridization, the FADD gene is mapped to 11q13.3. The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, thus, it participates in the death signaling initiated by these receptors.
CAS Number
9007-83-4
Specifications
Western blot: 1-2 µg/mL, Immunohistochemistry (FFPE) : 2-5 µg/mL
UniProt
Q8R2E7
Host
Rabbit
Reactivity
Rat, Mouse
Immunogen
Amino acids EKENASVAGLVKALRACRLNLVADLVEEALMAQ from the rat protein were used as the immunogen for the Fadd antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB, IHC-P
Purity
Affinity purified
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2% Trehalose and 0.0125% sodium azide
Reconstitution
After reconstitution, the Fadd antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This Fadd antibody is available for research use only.
Storage Conditions
After reconstitution, the Fadd antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
Optimal dilution of the Fadd antibody should be determined by the researcher.
Location
Cytoplasmic, nuclear
Image Legend
Immunofluorescent staining of FFPE rat liver cells with Fadd antibody (green) and DAPI nuclear stain (blue) . HIER: steam section in pH6 citrate buffer for 20 min.

UniProtKB · Q8R2E7

FAS-associated death domain protein

Q8R2E7_RAT · Rattus norvegicus

View on UniProt ↗
Primary accession
Q8R2E7
Review status
UniProtKB unreviewed (TrEMBL)
Gene
Fadd
Protein existence
1: Evidence at protein level
Organism
Rattus norvegicus (Rat)
Taxonomy ID
10116
Alternative names
—
EC number
—
Processing
—
Secondary accessions
—
Protein keywords

Biological process

ApoptosisImmunityInnate immunity

Cellular component

Cytoplasm

PTM

Phosphoprotein

Technical term

Proteomics identificationReference proteome

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