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Fadd Antibody

CAT: 0800-RQ6174Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-RQ6174Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
FADD, Fas-Associated protein with Death Domain, is a universal adaptor protein in apoptosis that mediates signaling of all known death domain-containing members of the TNF receptor superfamily. The FADD gene contains 2 exons and spans approximately 3.6 kb. By analysis of somatic cell hybrid panels and by fluorescence in situ hybridization, the FADD gene is mapped to 11q13.3. The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, thus, it participates in the death signaling initiated by these receptors.
CAS Number
9007-83-4
Specifications
Western blot: 1-2 µg/mL, Immunohistochemistry (FFPE) : 2-5 µg/mL, Flow cytometry: 1-3ug/million cells
UniProt
Q61160
Host
Rabbit
Reactivity
Mouse, Rat
Immunogen
Amino acids AEKKNASVAGLVKALRTCRLNLVADLVEEAQES from the mouse protein were used as the immunogen for the Fadd antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB, IHC-P, FACS
Purity
Affinity purified
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2% Trehalose and 0.0125% sodium azide
Reconstitution
After reconstitution, the Fadd antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This Fadd antibody is available for research use only.
Storage Conditions
After reconstitution, the Fadd antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
Optimal dilution of the Fadd antibody should be determined by the researcher.
Location
Cytoplasmic, nuclear
Image Legend
Western blot testing of rat 1) brain, 2) stomach, 3) lung, 4) liver, 5) kidney, 6) spleen, 7) thymus and 8) PC-12 lysate with Fadd antibody. Predicted molecular weight ~23 kDa, commonly observed at 23-28 kDa.

UniProtKB · Q61160

FAS-associated death domain protein

FADD_MOUSE · Mus musculus

View on UniProt ↗
Primary accession
Q61160
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
Fadd
Protein existence
1: Evidence at protein level
Organism
Mus musculus (Mouse)
Taxonomy ID
10090
Alternative names
—
EC number
—
Processing
—
Secondary accessions
Q3TC37, Q61082
Protein keywords

Technical term

3D-structureReference proteome

Biological process

ApoptosisImmunityInnate immunity

Cellular component

Cytoplasm

PTM

Phosphoprotein

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