Apc5 Antibody / Anaphase-promoting complex subunit 5

Apc5 Antibody / Anaphase-promoting complex subunit 5

• Description: Anaphase-promoting complex subunit 5 is an enzyme that in humans is encoded by the ANAPC5 gene. This gene encodes a tetratricopeptide repeat-containing component of the anaphase promoting complex/cyclosome (APC/C), a large E3 ubiquitin ligase that controls cell cycle progression by targeting a number of cell cycle regulators such as B-type cyclins for 26S proteasome-mediated degradation through ubiquitination. The encoded protein is required for the proper ubiquitination function of APC/C and for the interaction of APC/C with transcription coactivators. It also interacts with polyA binding protein and represses internal ribosome entry site-mediated translation. Multiple transcript variants encoding different isoforms have been found for this gene. These differences cause translation initiation at a downstream AUG and result in a shorter protein (isoform b), compared to isoform a.
• CAS Number: 9007-83-4
• UniProt: Q9UJX4
• Host: Rabbit
• Immunogen: A human recombinant partial protein (amino acids M1-D266) was used as the immunogen for the Apc5 antibody.
• Clonality: Polyclonal
• Isotype: IgG
• Applications: WB, IF, FACS, Direct ELISA
• Format: Antigen affinity purified
• Buffer: 0.5mg/ml if reconstituted with 0.2ml sterile DI water
• Reconstitution: After reconstitution, the Apc5 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
• Limitations: This Apc5 antibody is available for research use only.