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MASP2 Antibody

CAT: 0800-RQ6058Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-RQ6058Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Mannan-binding lectin serine protease 2 is a protein that in humans is encoded by the MASP2 gene. This gene is mapped to 1p36.22. This gene encodes a member of the peptidase S1 family of serine proteases. The encoded preproprotein is proteolytically processed to generate A and B chains that heterodimerize to form the mature protease. This protease cleaves complement components C2 and C4 in order to generate C3 convertase in the lectin pathway of the complement system. The encoded protease also plays a role in the coagulation cascade through cleavage of prothrombin to form thrombin. Myocardial infarction and acute stroke patients exhibit reduced serum concentrations of the encoded protein. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed.
CAS Number
9007-83-4
Specifications
Western blot: 0.5-1 µg/mL, Flow cytometry: 1-3ug/million cells
UniProt
O00187
Host
Rabbit
Reactivity
Human
Immunogen
Amino acids EAGQYGVYTKVINYIPWIENIISDF from the human protein were used as the immunogen for the MASP2 antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB, FACS
Purity
Affinity purified
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2% Trehalose and 0.025% sodium azide
Reconstitution
After reconstitution, the MASP2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This MASP2 antibody is available for research use only.
Storage Conditions
After reconstitution, the MASP2 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
Optimal dilution of the MASP2 antibody should be determined by the researcher.
Image Legend
Flow cytometry testing of human A431 cells with MASP2 antibody at 1ug/million cells (blocked with goat sera) ; Red=cells alone, Green=isotype control, Blue= MASP2 antibody.
Product Datasheet
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