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MECP2 Antibody

CAT: 0800-RQ5860Size: 100 µgDry Ice: NoHazardous: No
CAT#:0800-RQ5860Size:100 µg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
MECP2 (methyl CpG binding protein 2) is a gene that encodes the protein MECP2. It is mapped to Xq28. DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD) . Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. In contrast to other MBD family members, MECP2 is X-linked and subject to X inactivation. MECP2 is dispensible in stem cells, but is essential for embryonic development. MECP2 gene mutations are the cause of most cases of Rett syndrome, a progressive neurologic developmental disorder and one of the most common causes of cognitive disability in females. Alternative splicing results in multiple transcript variants encoding different isoforms.
CAS Number
9007-83-4
Specifications
Western blot: 0.5-1 µg/mL
UniProt
P51608
Host
Mouse
Reactivity
Human
Immunogen
Recombinant human protein (amino acids K119-R453) was used as the immunogen for the MECP2 antibody.
Clonality
Monoclonal
Isotype
IgG1
Clone
2G3
Applications
WB
Purity
Affinity purified
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2% Trehalose and 0.025% sodium azide
Reconstitution
After reconstitution, the MECP2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This MECP2 antibody is available for research use only.
Storage Conditions
After reconstitution, the MECP2 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
Optimal dilution of the MECP2 antibody should be determined by the researcher.
Image Legend
Western blot testing of human 1) U-87 MG, 2) HeLa, 3) K562, 4) HEK293 and 5) PC-3 lysate with MECP2 antibody. Expected molecular weight: ~55 kDa (unmodified) and ~75 kDa (modified) .

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