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NRF-2 Antibody / NFE2L2

CAT: 0800-RQ5744Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-RQ5744Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
NFE2L2 (nuclear factor (erythroid-derived 2) -like 2) also known as NRF2 or NFE2-RELATED TRANSCRIPTION FACTOR 2, is a transcription factor that in humans is encoded by the NFE2L2 gene. NFE2, NFE2L1, and NFE2L2 comprise a family of human genes encoding basic leucine zipper (bZIP) transcription factors. NFE2L2 induces the expression of various genes including those that encode for several antioxidant enzymes, and it may play a physiological role in the regulation of oxidative stress. The NFE2L2 gene is located on 2q31.2. The identification of somatic mutations that disrupt the NRF2-KEAP1 interaction to stabilize NRF2 and increase the constitutive transcription of NRF2 target genes indicated that enhanced reactive oxygen species (ROS) detoxification and additional NRF2 functions may in fact be tumorigenic. Oncogene-directed increased expression of Nrf2 is a mechanism for the activation of the Nrf2 antioxidant program evident in primary cells and tissues of mice expressing KRas (G12D) and BRaf (V619E), and in human pancreatic cancer.
CAS Number
9007-83-4
Specifications
Western blot: 0.5-1 µg/mL, Immunohistochemistry: 1-2 µg/mL, Immunofluorescence: 2-4 µg/mL, Flow cytometry: 1-3ug/million cells, Direct ELISA: 0.1-0.5 µg/mL
UniProt
Q16236
Host
Rabbit
Reactivity
Human
Immunogen
Recombinant human protein (amino acids R34-N605) was used as the immunogen for the NRF-2 antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB, IHC-P, IF, FACS, Direct ELISA
Purity
Affinity purified
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2% Trehalose and 0.025% sodium azide
Reconstitution
After reconstitution, the NRF-2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This NRF-2 antibody is available for research use only.
Storage Conditions
After reconstitution, the NRF-2 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
Optimal dilution of the NRF-2 antibody should be determined by the researcher.
Image Legend
IHC staining of FFPE human breast cancer with NRF-2 antibody. HIER: boil tissue sections in pH8 EDTA for 20 min and allow to cool before testing.

UniProtKB · Q16236

Nuclear factor erythroid 2-related factor 2

NF2L2_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q16236
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
NFE2L2
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
NF-E2-related factor 2, NFE2-related factor 2, Nrf-2
EC number
—
Processing
—
Secondary accessions
B2RBU2, B4E338, E9PGJ7, Q53RW6, Q59HH2, Q96F71
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

PTM

AcetylationGlycationGlycoproteinPhosphoproteinUbl conjugation

Molecular function

ActivatorDNA-binding

Coding sequence diversity

Alternative splicing

Cellular component

CytoplasmNucleus

Disease

Disease variant

Biological process

Host-virus interactionTranscriptionTranscription regulation

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