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Polycystin 2 Antibody

CAT: 0800-RQ5595Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-RQ5595Size:100 µg
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Description
Polycystin-2 is a protein that in humans is encoded by the PKD2 gene. It is mapped to 4q22.1. This gene encodes a member of the polycystin protein family. The encoded protein is a multi-pass membrane protein that functions as a calcium permeable cation channel, and is involved in calcium transport and calcium signaling in renal epithelial cells. This protein interacts with polycystin 1, and they may be partners in a common signaling cascade involved in tubular morphogenesis. Mutations in this gene are associated with autosomal dominant polycystic kidney disease type 2.
CAS Number
9007-83-4
Specifications
Western blot: 0.25-0.5 µg/mL, Immunohistochemistry (FFPE) : 1-2 µg/mL, Flow cytometry: 1-3ug/million cells, Direct ELISA: 0.1-0.5 µg/mL
UniProt
Q13563
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
A human recombinant protein (amino acids S829-R893) was used as the immunogen for the Polycystin 2 antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB, IHC-P, FACS, Direct ELISA
Purity
Affinity purified
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2% Trehalose and 0.025% sodium azide
Reconstitution
After reconstitution, the Polycystin 2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This Polycystin 2 antibody is available for research use only.
Storage Conditions
After reconstitution, the Polycystin 2 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
Optimal dilution of the Polycystin 2 antibody should be determined by the researcher.
Image Legend
IHC staining of FFPE human renal cancer with Polycystin 2 antibody. HIER: boil tissue sections in pH6, 10mM citrate buffer, for 20 min and allow to cool before testing.

UniProtKB · Q13563

Polycystin-2

PKD2_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q13563
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
PKD2
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
PC2
EC number
—
Processing
—
Secondary accessions
O60441, Q15764, Q2M1Q3, Q2M1Q5
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Ligand

CalciumMetal-bindingPotassium

Molecular function

Calcium channelIon channelPotassium channelVoltage-gated channel

Biological process

Calcium transportIon transportPotassium transportTransport

Cellular component

Cell membraneCell projectionCiliumCytoplasmic vesicleEndoplasmic reticulumGolgi apparatusMembraneSecreted

Disease

CiliopathyDisease variant

Domain

Coiled coilTransmembraneTransmembrane helix

PTM

Disulfide bondGlycoproteinMethylationPhosphoproteinUbl conjugation

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