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E-Cadherin Antibody / CDH1

CAT: 0800-RQ5389Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0800-RQ5389Size:100 µL
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Description
The CDH1 gene encodes a classical cadherin of the cadherin superfamily. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature glycoprotein. This calcium-dependent cell-cell adhesion protein is comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function of this gene is thought to contribute to cancer progression by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. [RefSeq]
CAS Number
9000-83-3
Specifications
Western blot: 1:1000-1:5000, Immunohistochemistry (FFPE) : 1:50-1:200
UniProt
P12830
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
A synthetic peptide specific to human E-Cadherin / CDH1 was used as the immunogen for the E-Cadherin antibody.
Clonality
Monoclonal
Isotype
IgG
Clone
COH-3
Type
Recombinant
Applications
IHC-P, WB
Purity
Affinity purified
Format
Purified
Buffer
Antibody in PBS with 0.02% sodium azide, 50% glycerol and 0.4-0.5mg/ml BSA
Reconstitution
Store the E-Cadherin antibody at -20oC.
Limitations
This E-Cadherin antibody is available for research use only.
Storage Conditions
Store the E-Cadherin antibody at -20°C.
Formulation
Antibody in PBS with 0.02% sodium azide, 50% glycerol and 0.4-0.5 mg/mL BSA
Applications Notes
Optimal dilution of the E-Cadherin antibody should be determined by the researcher.
Location
Cytoplasmic, plasma membrane
Image Legend
IHC staining of FFPE human colon cancer with E-Cadherin antibody. HIER: boil tissue sections in pH6, 10mM citrate buffer, for 10-20 min and allow to cool before testing.

UniProtKB · P12830

Cadherin-1

CADH1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P12830
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
CDH1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
Precursor
Secondary accessions
A8K1U7, Q13799, Q14216, Q15855, Q16194, Q4PJ14, Q9UII8
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Ligand

CalciumMetal-binding

Biological process

Cell adhesion

Cellular component

Cell junctionCell membraneCytoplasmEndosomeGolgi apparatusMembraneSecreted

PTM

Cleavage on pair of basic residuesDisulfide bondGlycoproteinPhosphoproteinUbl conjugation

Disease

Disease variantEctodermal dysplasia

Domain

RepeatSignalTransmembraneTransmembrane helix

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