PARP Antibody

• Description:

  The PARP1 gene encodes a chromatin-associated enzyme, poly (ADP-ribosyl) transferase, which modifies various nuclear proteins by poly (ADP-ribosyl) ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes. [RefSeq]

• Specifications:

  Western blot: 1:500-1:2000

• UniProt:

  P09874

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  A synthetic peptide specific to human PARP (auto-modification/catalytic segment) was used as the immunogen for the PARP antibody.

• Clonality:

  Monoclonal

• Isotype:

  IgG

• Clone:

  CFD-16

• Type:

  Recombinant

• Applications:

  WB

• Purity:

  Affinity purified

• Format:

  Purified

• Buffer:

  Antibody in PBS with 0.02% sodium azide, 50% glycerol and 0.4-0.5mg/ml BSA

• Reconstitution:

  Store the PARP antibody at -20oC.

• Limitations:

  This PARP antibody is available for research use only.

• Storage Conditions:

  Store the PARP antibody at -20°C.

• Formulation:

  Antibody in PBS with 0.02% sodium azide, 50% glycerol and 0.4-0.5 mg/mL BSA

• Applications Notes:

  Optimal dilution of the PARP antibody should be determined by the researcher.

• CAS Number:

  9000-83-3

• Image Legend:

  Western blot testing of human Jurkat cell lysate with PARP antibody. Predicted molecular weight ~116 kDa (full length), ~24 kDa (DNA-binding domain) .