P Glycoprotein Recombinant Antibody / MDR1 / ABCB1

• Description:

  The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier. [RefSeq]

• UniProt:

  P08183

• Host:

  Rabbit

• Immunogen:

  A synthetic peptide specific to human P Glycoprotein / ABCB1 / MDR1 was used as the immunogen for the MDR1 antibody.

• Clonality:

  Monoclonal

• Isotype:

  IgG

• Type:

  Recombinant

• Applications:

  WB

• Format:

  Purified

• Buffer:

  Antibody in PBS with 0.02% sodium azide, 50% glycerol and 0.4-0.5mg/ml BSA

• Reconstitution:

  Store the MDR1 antibody at -20oC.

• Limitations:

  This MDR1 antibody is available for research use only.

• CAS Number:

  9000-83-3