Phospho-Raf1 Recombinant Antibody / c-Raf (pS259)

Phospho-Raf1 Recombinant Antibody / c-Raf (pS259)

• Description: Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions including proliferation, differentiation, apoptosis, survival and oncogenic transformation. RAF1 activation initiates a mitogen-activated protein kinase (MAPK) cascade that comprises a sequential phosphorylation of the dual-specific MAPK kinases (MAP2K1/MEK1 and MAP2K2/MEK2) and the extracellular signal-regulated kinases (MAPK3/ERK1 and MAPK1/ERK2). [UniProt]
• CAS Number: 9000-83-3
• UniProt: P04049
• Host: Rabbit
• Immunogen: A synthetic peptide specific to human Raf1 (surrounding pS259) was used as the immunogen for the phospho-Raf1 antibody.
• Clonality: Monoclonal
• Isotype: IgG
• Type: Recombinant
• Applications: WB
• Format: Purified
• Buffer: Antibody in PBS with 0.02% sodium azide, 50% glycerol and 0.4-0.5mg/ml BSA
• Reconstitution: Store the phospho-Raf1 antibody at -20oC.
• Limitations: This phospho-Raf1 antibody is available for research use only.