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HMGCR Antibody

CAT: 0800-RQ5027Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0800-RQ5027Size:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
'3-hydroxy-3-methylglutaryl-coenzyme A reductase' is a transmembrane glycoprotein that is the rate-limiting enzyme in cholesterol biosynthesis as well as in the biosynthesis of nonsterol isoprenoids that are essential for normal cell function including ubiquinone and geranylgeranyl proteins.
CAS Number
9000-83-3
Specifications
Western blot: 1:500-1:2000
UniProt
P04035
Host
Rabbit
Reactivity
Human
Immunogen
A synthetic peptide specific to human Hmg Coa Reductase / HMGCR was used as the immunogen for the HMGCR antibody.
Clonality
Monoclonal
Isotype
IgG
Clone
AOCC-8
Type
Recombinant
Applications
WB
Purity
Affinity purified
Format
Purified
Buffer
Antibody in PBS with 0.02% sodium azide, 50% glycerol and 0.4-0.5mg/ml BSA
Reconstitution
Store the HMGCR antibody at -20oC.
Limitations
This HMGCR antibody is available for research use only.
Storage Conditions
Store the HMGCR antibody at -20°C.
Formulation
Antibody in PBS with 0.02% sodium azide, 50% glycerol and 0.4-0.5 mg/mL BSA
Applications Notes
Optimal dilution of the HMGCR antibody should be determined by the researcher.
Image Legend
Western blot testing of human Jurkat cell lysate with HMGCR antibody. Predicted molecular weight ~97 kDa.

UniProtKB · P04035

3-hydroxy-3-methylglutaryl-coenzyme A reductase

HMDH_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P04035
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
HMGCR
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
HMG-CoA reductase
EC number
1.1.1.34
Processing
—
Secondary accessions
B7Z3Y9, Q8N190
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Biological process

Cholesterol biosynthesisCholesterol metabolismLipid biosynthesisLipid metabolismSteroid biosynthesisSteroid metabolismSterol biosynthesisSterol metabolism

Disease

Disease variantLimb-girdle muscular dystrophy

Cellular component

Endoplasmic reticulumMembranePeroxisome

PTM

GlycoproteinIsopeptide bondPhosphoproteinUbl conjugation

Ligand

NADP

Molecular function

Oxidoreductase

Domain

TransmembraneTransmembrane helix
Product Datasheet
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