Dencichine

• Description :

  Dencichin is a non-protein amino acid originally extracted from Panax notoginseng, and can inhibit HIF-prolyl hydroxylase-2 (PHD-2) activity.

• Product Name Alternative :

  Dencichin; ODAP

• UNSPSC :

  12352211

• Hazard Statement :

  H302, H319, H372, H410

• Target :

  HIF/HIF Prolyl-Hydroxylase

• Type :

  Natural Products

• Related Pathways :

  Metabolic Enzyme/Protease

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/Dencichin.html

• Concentration :

  10mM

• Purity :

  99.59

• Solubility :

  0.1 M HCl : 3.33 mg/mL (ultrasonic; warming; heat to 60°C) |DMSO : 5 mg/mL (ultrasonic) |H2O : 5 mg/mL (ultrasonic)

• Smiles :

  N[C@@H](CNC(C(O)=O)=O)C(O)=O

• Molecular Formula :

  C5H8N2O5

• Molecular Weight :

  176.13

• Precautions :

  H302, H319, H372, H410

• References & Citations :

  [1]Eslavath RK, et al. β-N-oxalyl-L-α, β- diaminopropionic acid induces HRE expression by inhibiting HIF-prolyl hydroxylase-2 in normoxic conditions. Eur J Pharmacol. 2016 Nov 15;791:405-411.|[2]Jie L, et al. Dencichine ameliorates kidney injury in induced type II diabetic nephropathy via the TGF-β/Smad signalling pathway. Eur J Pharmacol. 2017 Oct 5;812:196-205.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  4°C (Powder, protect from light)

• Scientific Category :

  Natural Products

• Clinical Information :

  No Development Reported

• CAS Number :

  [5302-45-4]