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D6 Antibody / ACKR2

CAT: 0800-RQ4877Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-RQ4877Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
The ACKR2 gene encodes a beta chemokine receptor, called Chemokine Receptor D6, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptor-mediated signal transduction are critical for the recruitment of effector immune cells to the inflammation site. This gene is expressed in a range of tissues and hemopoietic cells. The expression of this receptor in lymphatic endothelial cells and overexpression in vascular tumors suggested its function in chemokine-driven recirculation of leukocytes and possible chemokine effects on the development and growth of vascular tumors. This receptor appears to bind the majority of beta-chemokine family members; however, its specific function remains unknown. This gene is mapped to chromosome 3p21.3, a region that includes a cluster of chemokine receptor genes.
CAS Number
9007-83-4
Specifications
Western blot: 0.5-1 µg/mL, Immunohistochemistry (FFPE) : 1-2 µg/mL, Direct ELISA: 0.1-0.5 µg/mL
UniProt
O00590
Host
Rabbit
Reactivity
Human
Immunogen
Amino acids M138-A384 from the human protein were used as the immunogen for the D6 antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB, IHC-P, Direct ELISA
Purity
Antigen affinity purified
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2% Trehalose and 0.025% sodium azide
Reconstitution
After reconstitution, the D6 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This D6 antibody is available for research use only.
Storage Conditions
After reconstitution, the D6 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
Optimal dilution of the D6 antibody should be determined by the researcher.
Image Legend
Western blot testing of human 1) Raji, 2) HeLa, and 3) SW620 cell lysate with D6 antibody at 0.5ug/ml. Predicted molecular weight ~43 kDa, can be observed at 50-55 kDa.

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