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HLA-DRB1 Antibody

CAT: 0800-RQ4649Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-RQ4649Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
HLA class II histocompatibility antigen, DRB1 beta chain is a protein that in humans is encoded by the HLA-DRB1 gene. This gene is mapped to 6p21.32. DRB1 encodes the most prevalent beta subunit of HLA-DR. Several alleles of DRB1 (shared epitope alleles) are associated with an increased incidence of rheumatoid arthritis. HLA-DRB1 belongs to the HLA class II beta chain paralogs. The class II molecule is a heterodimer consisting of an alpha (DRA) and a beta chain (DRB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages) . The beta chain is approximately 26-28 kDa. It is encoded by 6 exons. It plays a central role in the immune system by presenting peptides derived from extracellular proteins to T helper cells.
CAS Number
9007-83-4
Specifications
Western blot: 0.5-1 µg/mL
UniProt
P13761
Host
Rabbit
Reactivity
Human
Immunogen
Amino acids TERVQFLERLFYNQEEFVRFDSDVGEYRAVTELGR were used as the immunogen for the HLA-DRB1 antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB
Purity
Antigen affinity purified
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2% Trehalose and 0.025% sodium azide
Reconstitution
After reconstitution, the HLA-DRB1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This HLA-DRB1 antibody is available for research use only.
Storage Conditions
After reconstitution, the HLA-DRB1 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
Optimal dilution of the HLA-DRB1 antibody should be determined by the researcher.
Image Legend
Western blot testing of two lots of human Raji lysate with HLA-DRB1 antibody at 0.5ug/ml. Predicted molecular weight ~30 kDa.

UniProtKB · P01911

HLA class II histocompatibility antigen, DRB1 beta chain

DRB1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P01911
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
HLA-DRB1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
Precursor
Secondary accessions
A0MWF2, A0N0W1, A2ICT1, A2TGX3, A4F5N0, A4ZXA5, A4ZXA6, A4ZY86, A5H000, A5HKN8, A7DZP9, A7LA26, A7UHG2, A7X5B1, A7X5B7, A7X5E0, A7X5E6, A7X5H8, A7X5J4, A7X5K7, A8K098, A8YQE9, A9JPG0, B0BK85, B0LUZ6, B0UYW1, B1GWE7, B2CR03, B2LVF9, B2NJ29, B2ZCY1, B3VTP8, B3VTQ3, B5A8Y2, B5A8Y3, B5B8U0, B5B9V5, B5B9V6, B5LZ25, B5QSK8, B6VCX2, B6VEL9, B7UDB2, B9VRA4, B9X248, C0LAB5, O02876, O02930, O19585, O19717, O19718, O19739, O19788, O46699, O46793, O46872, O62869, O62889, O77969, O78047, O78210, O98212, P01912, P01914, P04229, P13758, P13759, P13760, P13761, P20039, P79545, Q06662, Q0PGR5, Q0PQ39, Q14280, Q14QT2, Q155F7, Q19AF2, Q19K86, Q1AP33, Q1G0Z9, Q1JRP3, Q1KLJ6, Q27PR6, Q27PR7, Q29673, Q29720, Q29722, Q29734, Q29770, Q29771, Q29772, Q29790, Q29792, Q29800, Q29806, Q29833, Q29874, Q29875, Q29886, Q29968, Q29974, Q29975, Q2A120, Q2HZE5, Q2L9H4, Q2LE76, Q2MF40, Q2MJA6, Q2MZ92, Q2VQU1, Q2YHQ2, Q30006, Q30108, Q30112, Q30115, Q30116, Q30117, Q30120, Q30134, Q30142, Q30145, Q30149, Q30159, Q30166, Q30167, Q30200, Q307W5, Q31636, Q32MY7, Q3HUP9, Q3KTM1, Q3LA84, Q3LA87, Q3LA88, Q3LA89, Q3LA90, Q3LA91, Q3LA92, Q3LA93, Q3LA94, Q3LA95, Q3LA96, Q3LA97, Q3LA98, Q3LA99, Q3LAA0, Q3LAA1, Q3LAA2, Q3MQ60, Q3T919, Q4PRC3, Q4PRC5, Q4VZY7, Q53IG1, Q56FN9, Q56FP1, Q56FP2, Q56FP3, Q58F52, Q5BM92, Q5EER6, Q5K3W2, Q5NDB9, Q5U9W6, Q5UBA2, Q5UT58, Q5W3L4, Q5Y7A7, Q5Y7B0, Q5Y7B9, Q5Y7E9, Q5Y7G0, Q683P7, Q6REE2, Q6T865, Q6U387, Q701T1, Q70GL2, Q70Q85, Q768U2, Q768U4, Q7M2H4, Q7YNY9, Q7YP03, Q7YP04, Q7YQ26, Q7YQA3, Q7YQA5, Q860D8, Q860D9, Q860E5, Q860H8, Q860S0, Q860Z3, Q861G6, Q861H0, Q861H4, Q861H5, Q861H7, Q861H8, Q8HWQ6, Q8MH59, Q8MH60, Q8WLU3, Q8WMA0, Q95348, Q95383, Q95389, Q95461, Q95HK1, Q95HL0, Q95HL1, Q95IE3, Q95IG2, Q95IT6, Q96HZ9, Q9BCL7, Q9BCP0, Q9BCP1, Q9BCP2, Q9BCP5, Q9BD21, Q9BD33, Q9BD40, Q9GIK5, Q9GIL5, Q9GIL6, Q9GIP3, Q9GIX8, Q9GIX9, Q9GIY0, Q9GIY1, Q9GIY2, Q9GIY3, Q9GIY4, Q9GJ25, Q9GJ56, Q9GJ57, Q9GJ58, Q9GJ60, Q9GJF8, Q9GJF9, Q9GJG0, Q9MXZ0, Q9MXZ5, Q9MY13, Q9MY45, Q9MY56, Q9MYF5, Q9TPB6, Q9TPW1, Q9TPW3, Q9TPW9, Q9TPX4, Q9TQ37, Q9TQ91, Q9TQE0, Q9UBY1, Q9UIM9, Q9UIN0, Q9XRX1, Q9XRY4, Q9XRY5, Q9Y453, Q9Y4H7
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Biological process

Adaptive immunityImmunity

Cellular component

Cell membraneCytoplasmic vesicleEndoplasmic reticulumEndosomeLysosomeMembraneMHC II

PTM

Disulfide bondGlycoproteinIsopeptide bondUbl conjugation

Domain

SignalTransmembraneTransmembrane helix

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