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Grancalcin Antibody / GCA

CAT: 0800-RQ4647Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-RQ4647Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Grancalcin is a protein that in humans is encoded by the GCA gene. This gene is mapped to 2q24.2. This gene product, grancalcin, is a calcium-binding protein abundant in neutrophils and macrophages. It belongs to the penta-EF-hand subfamily of proteins which includes sorcin, calpain, and ALG-2. Grancalcin localization is dependent upon calcium and magnesium. In the absence of divalent cation, grancalcin localizes to the cytosolic fraction; with magnesium alone, it partitions with the granule fraction; and in the presence of magnesium and calcium, it associates with both the granule and membrane fractions, suggesting a role for grancalcin in granule-membrane fusion and degranulation.
CAS Number
9007-83-4
Specifications
Western blot: 0.5-1 µg/mL, Immunohistochemistry (FFEP) : 2-5 µg/mL, Immunofluorescence: 5 µg/mL, Flow cytometry: 1-3ug/million cells, Direct ELISA: 0.1-0.5 µg/mL (human recombinant protein)
UniProt
P28676
Host
Rabbit
Reactivity
Human
Immunogen
Amino acids A42-I217 from the human protein were used as the immunogen for the Grancalcin antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB, IHC-P, IF, FACS, Direct ELISA
Purity
Antigen affinity purified
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2% Trehalose
Reconstitution
After reconstitution, the Grancalcin antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This Grancalcin antibody is for research use only.
Storage Conditions
After reconstitution, the Grancalcin antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
Optimal dilution of the Grancalcin antibody should be determined by the researcher.
Image Legend
Western blot testing of human 1) placenta, 2) HL-60 and 3) Caco-2 lysate with Grancalcin antibody at 0.5ug/ml. Predicted molecular weight ~24 kDa.

UniProtKB · P28676

Grancalcin

GRAN_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P28676
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
GCA
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
B2R5X3, Q53TB5, Q59EP3
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Ligand

CalciumMetal-binding

Cellular component

CytoplasmMembrane

Domain

Repeat

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