Products for Research Use Only
RegisterLogin

Bcl6 Antibody

CAT: 0800-RQ4637Size: 100 µgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0800-RQ4637Size:100 µg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
B-cell lymphoma 6 protein is a protein that in human is encoded by the BCL6 gene. Like BCL2, BCL3, BCL5, BCL7A, BCL9 and BCL10, it has clinical significance in lymphoma. The protein encoded by this gene is an evolutionarily conserved zinc finger transcription factor and contains an N-terminal POZ/BTB domain. This protein acts as a sequence-specific repressor of transcription and has been shown to modulate the STAT-dependent Interleukin 4 (IL-4) responses of B cells. This protein can interact with several corepressor complexes to inhibit transcription. This gene is found to be frequently translocated and hypermutated in diffuse large B cell lymphoma (DLBCL) and contributes to the pathogenesis of DLBCL. An exon 7 skipping splice variant encodes a shorter form of the protein which lacks the first two zinc fingers of the DNA binding domain.
CAS Number
9007-83-4
Specifications
Western blot: 0.5-1 µg/mL, IHC (FFPE) : 1-2 µg/mL, FACS: 1-3ug/million cells
UniProt
P41182
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Amino acids ASPADSCIQFTRHASDVLLNLNRLRSRDILTD were used as the immunogen for the Bcl6 antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB, IHC-P, FACS
Purity
Antigen affinity purified
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2% Trehalose and 0.025% sodium azide
Reconstitution
After reconstitution, the Bcl6 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This Bcl6 antibody is available for research use only.
Storage Conditions
After reconstitution, the Bcl6 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
Optimal dilution of the Bcl6 antibody should be determined by the researcher.
Location
Nuclear
Image Legend
Western blot testing of human 1) Raji, 2) MCF7, 3) placenta, 4) A549, 5) Caco-2 and 6) U-2 OS lysate with Bcl6 antibody at 0.5ug/ml. Predicted molecular weight: 78~100 kDa.

Related Products

CatalogName
V5023SAF-100UGB-Cell Lymphoma 6 Antibody / BCL6
V5023-100UGB-Cell Lymphoma 6 Antibody / BCL6
V5023-20UGB-Cell Lymphoma 6 Antibody / BCL6
V7145IHC-7MLBcl2 Antibody
V7145-100UGBcl2 Antibody
RQ5324BCL2 Antibody
RQ6314BCL3 Antibody
V7145-20UGBcl2 Antibody
V2833-100UGBcl2 Antibody
V7145SAF-100UGBcl2 Antibody

Alternative Products

CatalogName
33-840Bcl6 Antibody [BCL6/1527]
33-839Bcl6 Antibody [BCL6/1475]
33-802Bcl6 Antibody [BCL6/1526]
70R-11805BCL6 antibody

Popular Products