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COMT Antibody

CAT: 0800-RQ4554Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-RQ4554Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Catechol O-methyltransferase, also called COMT, is one of the major mammalian enzymes involved in the metabolic degradation of catecholamines. This gene is mapped to 22q11.21. Catechol-O-methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine. This O-methylation results in one of the major degradative pathways of the catecholamine transmitters. In addition to its role in the metabolism of endogenous substances, COMT is important in the metabolism of catechol drugs used in the treatment of hypertension, asthma, and Parkinson disease. COMT is found in two forms in tissues, a soluble form (S-COMT) and a membrane-bound form (MB-COMT) . The differences between S-COMT and MB-COMT reside within the N-termini.
CAS Number
9007-83-4
Specifications
Western blot: 0.5-1 µg/mL, Direct ELISA: 0.1-0.5 µg/mL (recombinant mouse protein)
UniProt
O88587
Host
Rabbit
Reactivity
Mouse
Immunogen
Amino acids R20-S265 from the mouse protein were used as the immunogen for the COMT antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB, Direct ELISA
Purity
Antigen affinity purified
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2% Trehalose and 0.025% sodium azide
Reconstitution
After reconstitution, the COMT antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Storage Conditions
After reconstitution, the COMT antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
Optimal dilution of the COMT antibody should be determined by the researcher.
Image Legend
Western blot testing of 1) mouse liver and 2) mouse stomach lysate with COMT antibody at 0.5ug//ml. Predicted molecular weight: ~30/25 kDa (isoforms 1/2) .
Product Datasheet
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