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MADCAM1 Antibody

CAT: 0800-RQ4529Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-RQ4529Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Mucosal Vascular Addressin Cell Adhesion Molecule 1 is a protein that in humans is encoded by the MADCAM1 gene. By PCR-based analysis of somatic cell hybrids, Leung et al. (1997) mapped the gene to chromosome 19. The protein encoded by this gene is an endothelil cell adhesion molecule that interacts preferentially with the leukocyte beta7 integrin LPAM-1 (alpha4 / beta7), L-selectin, and VLA-4 (alpha4/beta1) on myeloid cells to direct leukocytes into mucosal and inflamed tissues. It is a member of the immunoglobulin superfamily and is similar to ICAM-1 and VCAM-1.
CAS Number
9007-83-4
Specifications
Western blot: 0.5-1 µg/mL
UniProt
Q13477
Host
Rabbit
Reactivity
Human
Immunogen
Amino acids QELEGAQALGPEVQEEEEEPQGDEDVLFRVTERWRL were used as the immunogen for this MADCAM1 antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2% Trehalose and 0.025% sodium azide
Reconstitution
After reconstitution, the MADCAM1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This MADCAM1 antibody is available for research use only.
Storage Conditions
After reconstitution, the MADCAM1 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
The stated application concentrations are suggested starting amounts. Titration of the MADCAM1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Image Legend
Western blot testing of MADCAM1 antibody in HeLa cell lysate. Predicted molecular weight ~40 kDa.

UniProtKB · Q13477

Mucosal addressin cell adhesion molecule 1

MADCA_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q13477
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
MADCAM1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
MAdCAM-1, hMAdCAM-1
EC number
—
Processing
Precursor
Secondary accessions
A5PKV4, B2RPL9, O60222, O75867, Q5UGI7
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Biological process

Cell adhesion

PTM

Disulfide bondGlycoprotein

Domain

Immunoglobulin domainRepeatSignalTransmembraneTransmembrane helix

Cellular component

Membrane

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