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Talin 1 Antibody

CAT: 0800-RQ4466Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-RQ4466Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Talin-1 is a protein that in humans is encoded by the TLN1 gene. This gene encodes a cytoskeletal protein that is concentrated in areas of cell-substratum and cell-cell contacts. The encoded protein plays a significant role in the assembly of actin filaments and in spreading and migration of various cell types, including fibroblasts and osteoclasts. It codistributes with integrins in the cell surface membrane in order to assist in the attachment of adherent cells to extracellular matrices and of lymphocytes to other cells. The N-terminus of this protein contains elements for localization to cell-extracellular matrix junctions. The C-terminus contains binding sites for proteins such as beta-1-integrin, actin, and vinculin.
CAS Number
9007-83-4
Specifications
Western blot: 0.5-1 µg/mL, Immunohistochemistry (FFPE) : 1-2 µg/mL
UniProt
Q9Y490
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Amino acids QQLAPREGISQEALHTQMLTAVQEISHLIEPLANAARAEASQ were used as the immunogen for the Talin 1 antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB, IHC-P
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2% Trehalose and 0.025% sodium azide
Reconstitution
After reconstitution, the Talin 1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This Talin 1 antibody is available for research use only.
Storage Conditions
After reconstitution, the Talin 1 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
Optimal dilution of the Talin 1 antibody should be determined by the researcher.
Location
Cytoplasm, Cell surface
Image Legend
Western blot testing of 1) rat lung, 2) mouse lung, 3) human U-87 MG, 4) human MDA-MB-231 and 5) human HepG2 lysate with Talin 1 antibody. Predicted molecular weight ~275 kDa.

UniProtKB · Q9Y490

Talin-1

TLN1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q9Y490
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
TLN1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
A0A1S5UZ07, A6NMY0, Q86YD0, Q9NZQ2, Q9UHH8, Q9UPX3
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

PTM

AcetylationPhosphoprotein

Coding sequence diversity

Alternative splicing

Cellular component

Cell junctionCell membraneCell projectionCytoplasmCytoskeletonMembrane

Biological process

Host-virus interaction
Product Datasheet
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