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EOMES Antibody / Eomesodermin / TBR2

CAT: 0800-RQ4360Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-RQ4360Size:100 µg
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Description
Eomesodermin also known as T-box brain protein 2 (Tbr2) is a protein that in humans is encoded by the EOMES gene. This gene belongs to the TBR1 (T-box brain protein 1) sub-family of T-box genes that share the common DNA-binding T-box domain. The encoded protein is a transcription factor which is crucial for embryonic development of mesoderm and the central nervous system in vertebrates. The protein may also be necessary for the differentiation of effector CD8+ T cells which are involved in defense against viral infections. A similar gene disrupted in mice is shown to be essential during trophoblast development and gastrulation. Alternative splicing results in multiple transcript variants.
CAS Number
9007-83-4
Specifications
Western blot: 0.5-1 µg/mL, Direct ELISA: 0.1-0.5 µg/mL
UniProt
O95936
Host
Rabbit
Reactivity
Mouse, Rat
Immunogen
A recombinant human protein corresponding to amino acids T310-D532 was used as the immunogen for the EOMES antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB, ELISA
Purity
Antigen affinity purified
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2% Trehalose and 0.025% sodium azide
Reconstitution
After reconstitution, the EOMES antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This EOMES antibody is available for research use only.
Storage Conditions
After reconstitution, the EOMES antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
Optimal dilution of the EOMES antibody should be determined by the researcher.
Prediction Reactivity
Human
Location
Nuclear
Image Legend
Western blot testing of 1) rat spleen, 2) rat thymus, 3) mouse spleen and 4) mouse thymus lysate with EOMES antibody at 0.5ug/ml. Expected molecular weight: 73-85 kDa.

UniProtKB · O95936

Eomesodermin homolog

EOMES_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
O95936
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
EOMES
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
B7Z4I2, B7ZA51, G3XAI5, Q8TAZ2, Q9UPM7
Protein keywords

Molecular function

ActivatorDevelopmental proteinDNA-binding

Biological process

Adaptive immunityDifferentiationGastrulationImmunityTranscriptionTranscription regulation

Coding sequence diversity

Alternative splicingChromosomal rearrangement

Cellular component

Nucleus

PTM

Phosphoprotein

Technical term

Proteomics identificationReference proteome

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