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EGR1 Antibody

CAT: 0800-RQ4357Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-RQ4357Size:100 µg
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Description
Early growth response protein 1, also known as ZIF268 or NGFIA, is a protein that in humans is encoded by the EGR1 gene. The protein encoded by this gene belongs to the EGR family of C2H2-type zinc-finger proteins. This gene is mapped to 5q31.2. It is a nuclear protein and functions as a transcriptional regulator. The products of target genes it activates are required for differentitation and mitogenesis. Studies suggest this is a cancer suppresor gene. It has a distinct pattern of expression in the brain, and its induction has been shown to be associated with neuronal activity. Several studies suggest it has a role in neuronal plasticity.
CAS Number
9007-83-4
Specifications
Western blot: 0.5-1 µg/mL, Direct ELISA: 0.1-0.5 µg/mL
UniProt
P18146
Host
Rabbit
Reactivity
Human
Immunogen
A recombinant human protein corresponding to amino acids A239-R327 was used as the immunogen for the EGR1 antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB, ELISA
Purity
Antigen affinity purified
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2% Trehalose and 0.025% sodium azide
Reconstitution
After reconstitution, the EGR1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This EGR1 antibody is available for research use only.
Storage Conditions
After reconstitution, the EGR1 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
Optimal dilution of the EGR1 antibody should be determined by the researcher.
Location
Nuclear, cytoplasmic
Image Legend
Western blot testing of human 1) 22RV1 and 2) PANC-1 cell lysate with EGR1 antibody at 0.5ug/ml. Predicted molecular weight: 57 kDa (monomer), ~110 kDa (cytoplasmic dimer), ~75 kDa (nuclear dimer) .

UniProtKB · P18146

Early growth response protein 1

EGR1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P18146
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
EGR1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
EGR-1
EC number
—
Processing
—
Secondary accessions
—
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Molecular function

ActivatorDNA-binding

Biological process

Biological rhythmsTranscriptionTranscription regulation

Cellular component

CytoplasmNucleus

PTM

Isopeptide bondUbl conjugation

Ligand

Metal-bindingZinc

Domain

RepeatZinc-finger

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CatalogName
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