SCRIB Antibody / SCRIBBLE

SCRIB Antibody / SCRIBBLE

• Description: SCRIB, also known as Scribble, SCRIBL, or Scribbled homolog (Drosophila), is a scaffold protein which in humans is encoded by the SCRIB gene. In Drosophila melanogaster, SCRIB is involved in synaptic function, neuroblast differentiation, and epithelial polarization. Mechanistically, the human homolog is a scaffold protein linked to cellular differentiation centered on the regulation of epithelial as well as neuronal morphogenesis. Deficiency in SCRIB impairs many aspects of cell polarity and cell movement. SCRIB is also likely involved in establishing apical-basal polarity as well as progression from the G1 phase to S phase in the cell cycle as a result of its relationship with cell proliferation and exocytosis.
• CAS Number: 9007-83-4
• UniProt: Q14160
• Host: Rabbit
• Immunogen: A recombinant human protein corresponding to amino acids F172-K409 was used as the immunogen for the SCRIB antibody.
• Clonality: Polyclonal
• Isotype: IgG
• Applications: WB, FACS, IF/ICC, ELISA
• Format: Antigen affinity purified
• Buffer: 0.5mg/ml if reconstituted with 0.2ml sterile DI water
• Reconstitution: After reconstitution, the SCRIB antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
• Limitations: This SCRIB antibody is available for research use only.