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CUL4A Antibody

CAT: 0800-RQ4317Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-RQ4317Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Cullin-4A is a protein that in humans is encoded by the CUL4A gene. It belongs to the cullin family of ubiquitin ligase proteins and is highly homologous to the CUL4B protein. CUL4A regulates numerous key processes such as DNA repair, chromatin remodeling, spermatogenesis, haematopoiesis and the mitotic cell cycle. As a result, CUL4A has been implicated in several cancers and the pathogenesis of certain viruses including HIV. Interestingly, a component of a CUL4A complex, Cereblon, was discovered to be a major target of the teratogenic agent thalidomide.
CAS Number
9007-83-4
Specifications
Western blot: 0.5-1 µg/mL, Direct ELISA: 0.1-0.5 µg/mL
UniProt
Q13619
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
A recombinant human protein corresponding to amino acids M494-A759 was used as the immunogen for the CUL4A antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB, ELISA
Purity
Antigen affinity purified
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2% Trehalose and 0.025% sodium azide
Reconstitution
After reconstitution, the CUL4A antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This CUL4A antibody is available for research use only.
Storage Conditions
After reconstitution, the CUL4A antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
Optimal dilution of the CUL4A antibody should be determined by the researcher.
Image Legend
Western blot testing of human 1) HeLa, 2) COLO-320, 3) MDA-MB-231, 4) Jurkat and 5) PANC-1 cell lysate with CUL4A antibody at 0.5ug/ml. Predicted molecular weight ~88 kDa.
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