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DGCR8 Antibody

CAT: 0800-RQ4228Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-RQ4228Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
The DGCR8 microprocessor complex subunit (DiGeorge syndrome chromosomal [or critical] region 8) is a protein that in humans is encoded by the DGCR8 gene. This gene encodes a subunit of the microprocessor complex which mediates the biogenesis of microRNAs from the primary microRNA transcript. The encoded protein is a double-stranded RNA binding protein that functions as the non-catalytic subunit of the microprocessor complex. This protein is required for binding the double-stranded RNA substrate and facilitates cleavage of the RNA by the ribonuclease III protein, Drosha. Alternate splicing results in multiple transcript variants.
CAS Number
9007-83-4
Specifications
Western blot: 0.5-1 µg/mL, IHC (FFPE) : 1-2 µg/mL, Direct ELISA: 0.1-0.5 µg/mL
UniProt
Q8WYQ5
Host
Rabbit
Reactivity
Human
Immunogen
A recombinant human protein corresponding to amino acids K561-Q762 was used as the immunogen for the DGCR8 antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB, IHC-P, ELISA
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2% Trehalose and 0.025% sodium azide
Reconstitution
After reconstitution, the DGCR8 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This DGCR8 antibody is available for research use only.
Storage Conditions
After reconstitution, the DGCR8 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
Optimal dilution of the DGCR8 antibody should be determined by the researcher.
Location
Nuclear
Image Legend
Western blot testing of human 1) HeLa, 2) placenta, 3) COLO320, 4) HepG2, 5) A549, 6) MCF7 and 7) 22RV1 lysate with DGCR8 antibody at 0.5ug/ml. Predicted molecular weight ~86 kDa but can be observed up to ~120 kDa.

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