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CD2AP Antibody

CAT: 0800-RQ4204Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-RQ4204Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CD2-associated protein is a protein that in humans is encoded by the CD2AP gene. This gene encodes a scaffolding molecule that regulates the actin cytoskeleton. The protein directly interacts with filamentous actin and a variety of cell membrane proteins through multiple actin binding sites, SH3 domains, and a proline-rich region containing binding sites for SH3 domains. The cytoplasmic protein localizes to membrane ruffles, lipid rafts, and the leading edges of cells. It is implicated in dynamic actin remodeling and membrane trafficking that occurs during receptor endocytosis and cytokinesis. Haploinsufficiency of this gene is implicated in susceptibility to glomerular disease.
CAS Number
9007-83-4
Specifications
Western blot: 1-2 µg/mL, Flow cytometry: 1-3ug/million cells, Immunohistochemistry (FFPE) : 2-5 µg/mL, Immunofluorescence: 5 µg/mL, ELISA: 0.1-0.5 µg/mL, Immunoprecipitation: 2ug antibody/500ug lysate
UniProt
Q9Y5K6
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
A recombinant human protein corresponding to amino acids K253-K337 was used as the immunogen for the CD2AP antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB, FACS, IHC-P, IF, IP, ELISA
Purity
Antigen affinity purified
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2% Trehalose
Reconstitution
After reconstitution, the CD2AP antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This CD2AP antibody is available for research use only.
Storage Conditions
After reconstitution, the CD2AP antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
Optimal dilution of the CD2AP antibody should be determined by the researcher.
Image Legend
Western blot testing of human 1) HeLa, 2) 293T, 3) MCF7, 4) COLO320, 5) 22RV1 6) SK-OV-3, 7) rat stomach, 8) rat liver and 9) mouse liver lysate wtih CD2AP antibody at 0.5ug/ml. Predicted molecular weight: 71-80 kDa.

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