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DYNLT1 Antibody / TCTEX1

CAT: 0800-RQ4143Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-RQ4143Size:100 µg
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Description
Dynein light chain Tctex-type 1 is a protein that in humans is encoded by the DYNLT1 gene. This gene encodes a component of the motor complex, cytoplasmic dynein, which transports cellular cargo along microtubules in the cell. The encoded protein regulates the length of primary cilia which are sensory organelles found on the surface of cells. The protein encoded by this gene interacts with viral proteins, like the minor capsid protein L2 of human papillomavirus, and is required for dynein-mediated delivery of the viral nucleic acid to the host nucleus. This protein interacts with oncogenic nucleoporins to disrupt gene regulation and cause leukemic transformation. Pseudogenes of this gene are present on chromosomes 4 and 17. Alternative splicing results in multiple transcript variants encoding different isoforms.
CAS Number
9007-83-4
Specifications
Western Blot: 0.5-1 µg/mL, Immunohistochemistry (FFPE) : 2-5 µg/mL, Immunofluorescence: 5 µg/mL, Direct ELISA: 0.1-0.5 µg/mL
UniProt
P63172
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
A recombinant human partial protein corresponding to amino acids M1-A80 was used as the immunogen for the DYNLT1 antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB, IHC-P, IF, ELISA
Purity
Antigen affinity purified
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2% Trehalose
Reconstitution
After reconstitution, the DYNLT1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This DYNLT1 antibody is available for research use only.
Storage Conditions
After reconstitution, the DYNLT1 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
Optimal dilution of the DYNLT1 antibody should be determined by the researcher.
Location
Cytoplasmic
Image Legend
Immunofluorescent staining of FFPE human testis cancer tissue with DYNLT1 antibody (red) and DAPI nuclear stain (blue) . HIER: steam section in pH8 EDTA buffer for 20 min.

UniProtKB · P63172

Dynein light chain Tctex-type 1

DYLT1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P63172
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
DYNLT1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
Q15763, Q5VTU4
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

PTM

AcetylationPhosphoprotein

Biological process

Cell cycleCell divisionCytoplasmic inwards viral transportHost-virus interactionMicrotubular inwards viral transportMitosisNeurogenesisTransportVirus entry into host cell

Cellular component

CytoplasmCytoskeletonDyneinGolgi apparatusMicrotubule

Molecular function

Motor protein
Product Datasheet
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