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HSF2 Antibody / Heat shock factor 2

CAT: 0800-RQ4139Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-RQ4139Size:100 µg
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Description
HSF2 (Heat shock transcription factor 2), also called Heat shock factor 2, as well as the related gene HSF1, encodes a protein that binds specifically to the heat-shock element and has homology to HSFs of other species. The International Radiation Hybrid Mapping Consortium maps the HSF2 gene to chromosome 6. Mouse Hsf2 was expressed in all 3 embryonic layers at embryonic day 7.5 and that the head fold was strongly stained at embryonic day 8.5. In adults, Hsf2 expression is detected in spermatocytes and spermatogonia, but not in elongated spermatids, spermatozoa, or Sertoli cells. Hsp70i bookmarking is mediated by a transcription factor called HSF2, which binds this promoter in mitotic cells, recruits protein phosphatase-2A, and interacts with the CAPG subunit of the condensin enzyme to promote efficient dephosphorylation and inactivation of condensin complexes in the vicinity, thereby preventing compaction at this site. And Hsf2-null mice were born at the expected mendelian ratio but had brain abnormalities and meiotic and gametogenic defects in both genders.
CAS Number
9007-83-4
Specifications
Western Blot: 0.5-1 µg/mL, Direct ELISA: 0.1-0.5 µg/mL
UniProt
Q03933
Host
Rabbit
Reactivity
Human
Immunogen
A recombinant human partial protein corresponding to amino acids K13-D245 was used as the immunogen for the HSF2 antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB, ELISA
Purity
Antigen affinity purified
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2% Trehalose and 0.025% sodium azide
Reconstitution
After reconstitution, the HSF2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This HSF2 antibody is available for research use only.
Storage Conditions
After reconstitution, the HSF2 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
Optimal dilution of the HSF2 antibody should be determined by the researcher.
Location
Cytoplasmic, nuclear
Image Legend
Western blot testing of human 1) placenta, 2) HepG2 and 3) MCF7 lysate with HSF2 antibody at 0.5ug/ml. Predicted molecular weight ~60 kDa.

UniProtKB · Q03933

Heat shock factor protein 2

HSF2_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q03933
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
HSF2
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
HSF 2
EC number
—
Processing
—
Secondary accessions
B4DGJ4, Q0VAH9, Q2M1K4, Q9H445
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Molecular function

ActivatorDNA-binding

Coding sequence diversity

Alternative splicing

Cellular component

CytoplasmNucleus

PTM

Isopeptide bondUbl conjugation

Biological process

Stress responseTranscriptionTranscription regulation
Product Datasheet
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