EEA1 Antibody

CAT: 0800-RQ4105Size: 100 µgDry Ice: NoHazardous: No
CAT#:0800-RQ4105Size:100 µg
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Description
The gene EEA1 encodes for the 1400 amino acid protein, Early Endosome Antigen 1. It localizes exclusively to early endosomes and has an important role in endosomal trafficking. EEA1 binds directly to the phospholipid phosphatidylinositol 3-phosphate through its C-terminal FYVE domain and forms ahomodimer through a coiled coil. Furthermore, EEA1 acts as a tethering molecule that couples vesicle docking with SNAREs such as N-ethylmaleimide sensitive fusion protein, bringing the endosomes physically closer and ultimately resulting in the fusion and delivery of endosomal cargo.
CAS Number
9007-83-4
Specifications
Western Blot: 0.5-1 µg/mL, Immunohistochemistry (FFPE) : 2-5 µg/mL, Immunofluorescence: 5 µg/mL
UniProt
Q15075
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Amino acids RENQSLQIKHTQALNRKWAEDNEVQN from the human protein were used as the immunogen for the EEA1 antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB, IHC-P, IF
Purity
Antigen affinity purified
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2% Trehalose and 0.025% sodium azide
Reconstitution
After reconstitution, the EEA1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This EEA1 antibody is available for research use only.
Storage Conditions
After reconstitution, the EEA1 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
Optimal dilution of the EEA1 antibody should be determined by the researcher.
Location
Cytoplasm
Image Legend
Western blot testing of human 1) HeLa, 2) placenta, 3) COLO320, 4) 22RV1 and 5) A549 lysate with EEA1 antibody at 0.5ug/ml. Predicted molecular weight ~162 kDa.

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E19-8248-2EEA1 Antibody

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