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Gp91phox Antibody / NOX2 / CYBB

CAT: 0800-RQ4016Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-RQ4016Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
NOX2 (NADPH Oxidase 2), also called CYBB (Cytochrome b (-245), beta subunit), p91-PHOX or GP91-1, is a human gene encoding a glycoprotein. NOX2 is an essential component of phagocytic NADPH-oxidase, a membrane-bound enzyme complex that generates large quantities of microbicidal superoxide and other oxidants upon activation. It is mapped on Xp11.4. NOX2 assembled on DC phagosomes in a gp91-phox subunit-dependent manner, and that reactive oxygen species were produced in a more sustained manner in immature DC phagosomes than in macrophage phagosomes. As a major player in innate immune responses in neutrophils, NOX2 is also involved in adaptive immunity through its activity in DCs. In heart cells, physiologic stretch rapidly activates reduced-form NOX2 to produce reactive oxygen species (ROS) in a process dependent on microtubules (X-ROS signaling) .
CAS Number
9007-83-4
Specifications
Western Blot: 0.5-1 µg/mL, Direct ELISA: 0.1-0.5 µg/mL
UniProt
P04839
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
A recombinant human partial protein corresponding to amino acids F416-D500 was used as the immunogen for the gp91phox antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB, ELISA
Purity
Antigen affinity purified
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2% Trehalose and 0.025% sodium azide
Reconstitution
After reconstitution, the gp91phox antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This gp91phox antibody is available for research use only.
Storage Conditions
After reconstitution, the gp91phox antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
Optimal dilution of the gp91phox antibody should be determined by the researcher.
Image Legend
Western blot testing of human 1) U-87 MG, 2) HeLa and 3) HepG2 cell lysate with NOX2 antibody at 0.5ug/ml. Predicted molecular weight ~65 kDa, can be observed at ~85 kDa.

UniProtKB · P04839

NADPH oxidase 2

CY24B_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P04839
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
CYBB
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
1.6.3.-
Processing
—
Secondary accessions
A8K138, Q2PP16
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Cellular component

Cell membraneMembrane

Disease

Chronic granulomatous diseaseDisease variant

Biological process

Electron transportIon transportTransport

Ligand

FADFlavoproteinHemeIronMetal-bindingNADP

PTM

GlycoproteinIsopeptide bondPhosphoproteinUbl conjugation

Molecular function

Ion channelOxidoreductaseVoltage-gated channel

Domain

TransmembraneTransmembrane helix
Product Datasheet
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