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MUC1 Antibody

CAT: 0800-RQ4004Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-RQ4004Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Mucin 1, cell surface associated (MUC1) or polymorphic epithelial mucin (PEM) is a mucin encoded by the MUC1 gene in humans. This gene encodes a membrane-bound protein that is a member of the mucin family. Mucins are O-glycosylated proteins that play an essential role in forming protective mucous barriers on epithelial surfaces. It is mapped to 1q22. Mucin 1 is a transmembrane mucin normally expressed on the apical borders of secretory epithelial cells. Overexpression of Mucin 1 is often associated with colon, breast, ovarian, lung and pancreatic cancers. The protein serves a protective function by binding to pathogens and also functions in a cell signaling capacity. Mucin 1 stimulated ESR1-mediated transcription and contributed to estradiol-mediated growth and survival of breast cancer cells. This gene also can suppress pulmonary innate immunity, and its antiinflammatory activity may play an important modulatory role during microbial infection.
CAS Number
9007-83-4
Specifications
Western Blot: 0.5-1 µg/mL, IHC (FFPE) : 1-2 µg/mL, Direct ELISA: 0.1-0.5 µg/mL
UniProt
P15941
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
A recombinant human partial protein corresponding to amino acids S1062-V1139 was used as the immunogen for the MUC1 antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB, IHC-P, ELISA
Purity
Antigen affinity purified
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2% Trehalose and 0.025% sodium azide
Reconstitution
After reconstitution, the MUC1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This MUC1 antibody is available for research use only.
Storage Conditions
After reconstitution, the MUC1 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
Optimal dilution of the MUC1 antibody should be determined by the researcher.
Location
Cytoplasmic, membranous
Image Legend
Western blot testing of 1) rat lung, 2) rat pancreas and 3) mouse pancreas with MUC1 antibody at 0.5ug/ml. Expected molecular weight: 120-500 kDa depending on glycosylation level.

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