CNGB3 Antibody

• Description :

  Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. Cyclic nucleotide-gated cation channel beta-3 can be activated by cGMP which leads to an opening of the cation channel and thereby causing a depolarization of rod photoreceptors. Induced a flickering channel gating, weakened the outward rectification in the presence of extracellular calcium, increased sensitivity for L-cis diltiazem and enhanced the cAMP efficiency of the channel when coexpressed with CNGA3 (By similarity) . Essential for the generation of light-evoked electrical responses in the red-, green- and blue sensitive cones. [UniProt]

• Specifications :

  IHC (FFPE) : 2-4 µg/mL, ELISA (peptide) LOD: 1:8000

• UniProt :

  Q9NQW8

• Host :

  Goat

• Reactivity :

  Human

• Immunogen :

  Amino acids ESDDKPTEHYYR were used as the immunogen for this CNGB3 antibody.

• Clonality :

  Polyclonal

• Isotype :

  Ig

• Applications :

  IHC-P, ELISA (peptide)

• Purity :

  Antigen affinity

• Format :

  Antigen affinity purified

• Buffer :

  0.5 mg/ml in 1X TBS, pH7.3, with 0.5% BSA (US sourced) and 0.02% sodium azide

• Reconstitution :

  Aliquot and store the CNGB3 antibody at -20oC.

• Limitations :

  This CNGB3 antibody is available for research use only.

• Storage Conditions :

  Aliquot and store the CNGB3 antibody at -20°C.

• Formulation :

  0.5 mg/mL in 1X TBS, pH7.3, with 0.5% BSA (US sourced) and 0.02% sodium azide

• Applications Notes :

  Optimal dilution of the CNGB3 antibody should be determined by the researcher.

• CAS Number :

  9007-83-4

• Image Legend :

  IHC testing of FFPE human retinal with CNGB3 antibody at 2ug/ml. Staining of the pigmented epithelial cells is seen.