BI-2865
CAT:
804-HY-153724-05
Size:
25 mg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
BI-2865
- CAS Number: 2937327-93-8
- UNSPSC Description: BI-2865 is a none-covalent pan-KRAS Inhibitor. BI-2865 binds to WT, G12C, G12D, G12V and G13D mutant KRAS with KDs of 6.9, 4.5, 32, 26, 4.3 nM respectively. BI-2865 inhibits the proliferation of G12C, G12D or G12V mutant KRAS expressing BaF3 cells (mean IC50: roughly 140 nM)[1].
- Target Antigen: Ras
- Type: Reference compound
- Related Pathways: GPCR/G Protein;MAPK/ERK Pathway
- Applications: Cancer-Kinase/protease
- Field of Research: Cancer
- Assay Protocol: https://www.medchemexpress.com/bi-2865.html
- Solubility: DMSO : 250 mg/mL (ultrasonic)
- Smiles: N#CC1=C(N)SC2=C1[C@@](C)(C3=NC(C4=NC(O[C@@H](C)[C@@H]5CCCN5C)=CC=N4)=NO3)CCC2
- Molecular Weight: 465.57
- References & Citations: [1]Kim D, et al. Pan-KRAS inhibitor disables oncogenic signalling and tumour growth. Nature. 2023 May 31.
- Shipping Conditions: Room Temperature
- Clinical Information: No Development Reported