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CD40 Antibody

CAT: 0800-R32996Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-R32996Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
This CD40 gene is a member of the TNF-receptor superfamily. The encoded protein is a receptor on antigen-presenting cells of the immune system and is essential for mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Mutations affecting this gene are the cause of autosomal recessive hyper-IgM immunodeficiency type 3 (HIGM3) . Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
CAS Number
9007-83-4
Specifications
Western Blot: 0.5-1 µg/mL, Direct ELISA: 0.1-0.5 µg/mL
UniProt
Q4QQW2
Host
Rabbit
Reactivity
Mouse, Rat
Immunogen
A recombinant rat partial protein corresponding to amino acids V24-R193 was used as the immunogen for the CD40 antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB, ELISA
Purity
Antigen affinity purified
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2% Trehalose and 0.025% sodium azide
Reconstitution
After reconstitution, the CD40 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This CD40 antibody is available for research use only.
Storage Conditions
After reconstitution, the CD40 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
Optimal dilution of the CD40 antibody should be determined by the researcher.
Image Legend
Western blot testing of rat PC-12 cell lysate with CD40 antibody at 0.5ug/ml. Predicted molecular weight is 30-45 kDa depending on glycosylation level.

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