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WFDC2 Antibody / HE4

CAT: 0800-R32930Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-R32930Size:100 µg
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Description
WAP four-disulfide core domain protein 2, also known as Human Epididymis Protein 4 (HE4), is a protein that in humans is encoded by the WFDC2 gene. This gene encodes a protein that is a member of the WFDC domain family. The WFDC domain, or WAP Signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor in many family members. This gene is expressed in pulmonary epithelial cells, and was also found to be expressed in some ovarian cancers. The encoded protein is a small secretory protein, which may be involved in sperm maturation.
CAS Number
9007-83-4
Specifications
Western Blot: 0.5-1 µg/mL, Immunohistochemistry (FFPE) : 1-2 µg/mL
UniProt
Q8CHN3
Host
Rabbit
Reactivity
Mouse, Rat
Immunogen
A recombinant rat protein corresponding to amino acids E31-F168 was used as the immunogen for the WFDC2 antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB, IHC-P
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2% Trehalose and 0.025% sodium azide
Reconstitution
After reconstitution, the WFDC2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This WFDC2 antibody is available for research use only.
Storage Conditions
After reconstitution, the WFDC2 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
Optimal dilution of the WFDC2 antibody should be determined by the researcher.
Location
Cytoplasmic, secreted
Image Legend
Western blot testing of 1) rat testis, 2) rat brain, 3) rat thymus, 4) mouse testis, 5) mouse brain, 6) mouse thymus and 7) mouse HEPA1-6 lysate with WFDC2 antibody at 0.5ug/ml. Expected molecular weight: 13-25 kDa, depending on glycosylation level.

UniProtKB · Q8CHN3

WAP four-disulfide core domain protein 2

WFDC2_RAT · Rattus norvegicus

View on UniProt ↗
Primary accession
Q8CHN3
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
Wfdc2
Protein existence
2: Evidence at transcript level
Organism
Rattus norvegicus (Rat)
Taxonomy ID
10116
Alternative names
—
EC number
—
Processing
Precursor
Secondary accessions
Q8CHN1
Protein keywords

Coding sequence diversity

Alternative splicing

Molecular function

Aspartic protease inhibitorProtease inhibitorSerine protease inhibitorThiol protease inhibitor

PTM

Disulfide bond

Technical term

Reference proteome

Domain

RepeatSignal

Cellular component

Secreted

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