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Il12 p40 Antibody

CAT: 0800-R32886Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-R32886Size:100 µg
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Description
Subunit beta of interleukin 12 (IL12B), also known as interleukin 12B, or interleukin-12 subunit p40, is a subunit of human interleukin 12. It is mapped to 5q33.3. This cytokine is expressed by activated macrophages that serve as an essential inducer of Th1 cells development. This cytokine has been found to be important for sustaining a sufficient number of memory/effector Th1 cells to mediate long-term protection to an intracellular pathogen. Overexpression of this gene was observed in the central nervous system of patients with multiple sclerosis (MS), suggesting a role of this cytokine in the pathogenesis of the disease.
CAS Number
9007-83-4
Specifications
Western Blot: 0.5-1 µg/mL, Direct ELISA (recombinant mouse protein) : 0.1-0.5 µg/mL (BSA-free format available)
UniProt
P43432
Host
Rabbit
Reactivity
Mouse
Immunogen
A recombinant mouse protein corresponding to amino acids M23-E250 was used as the immunogen for the Il12 p40 antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB, Direct ELISA
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide
Reconstitution
After reconstitution, the Il12 p40 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This Il12 p40 antibody is available for research use only.
Storage Conditions
After reconstitution, the Il12 p40 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
Optimal dilution of the Il12 p40 antibody should be determined by the researcher.
Image Legend
Western blot testing of mouse kidney tissue with Il12 p40 antibody at 0.5ug/ml. Predicted molecular weight 37-40 kDa.

UniProtKB · P43432

Interleukin-12 subunit beta

IL12B_MOUSE · Mus musculus

View on UniProt ↗
Primary accession
P43432
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
Il12b
Protein existence
1: Evidence at protein level
Organism
Mus musculus (Mouse)
Taxonomy ID
10090
Alternative names
IL-12B
EC number
—
Processing
Precursor
Secondary accessions
Q9QUM1
Protein keywords

Technical term

3D-structureReference proteome

Molecular function

Cytokine

PTM

Disulfide bondGlycoprotein

Domain

Immunoglobulin domainSignal

Cellular component

Secreted

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