MBL2 Antibody / Mannose-Binding Lectin 2

CAT: 0800-R32879Size: 100 µgDry Ice: NoHazardous: No

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CAT#:0800-R32879Size:100 µg

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Description

MBL2, also called mannose-binding lectin (protein C) 2, soluble or Mannose-binding lectin (MBL) is a lectin that is instrumental in innate immunity. MBL2 is mapped to chromosome 10q11.2-q21. It belongs to the class of collectins in the C-type lectin superfamily, whose function appears to be pattern recognition in the first line of defense in the pre-immune host. MBL2 recognizes carbohydrate patterns, found on the surface of a large number of pathogenic micro-organisms, including bacteria, viruses, protozoa and fungi. Binding MBL2 to a micro-organism results in activation of the lectin pathway of the complement system. Another important function of MBL2 is that this molecule binds senescent and apoptotic cells and enhances engulfment of whole, intact apoptotic cells, as well as cell debris by phagocytes.

CAS Number

9007-83-4

Specifications

Western Blot: 0.5-1 µg/mL, IHC (FFPE) : 1-2 µg/mL, Direct ELISA (recombinant rat protein) : 0.1-0.5 µg/mL (BSA-free format available)

UniProt

P08661

Host

Rabbit

Reactivity

Mouse, Rat

Immunogen

A recombinant rat protein corresponding to amino acids E19-D244 was used as the immunogen for the MBL2 antibody.

Clonality

Polyclonal

Isotype

IgG

Applications

WB, IHC-P, Direct ELISA

Purity

Antigen affinity

Format

Antigen affinity purified

Buffer

Lyophilized from 1X PBS with 2.5% BSA, 0.025% sodium azide

Reconstitution

After reconstitution, the MBL2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Limitations

This MBL2 antibody is available for research use only.

Storage Conditions

After reconstitution, the MBL2 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Formulation

0.5 mg/mL if reconstituted with 0.2ml sterile DI water

Applications Notes

Optimal dilution of the MBL2 antibody should be determined by the researcher.

Location

Secreted

Image Legend

Western blot testing of 1) rat liver, 2) mouse liver and 3) mouse HEPA1-6 lysate with MBL2 antibody at 0.5ug/ml. Predicted molecular weight ~26 kDa.

UniProtKB · P08661

Mannose-binding protein C

MBL2_RAT · Rattus norvegicus

View on UniProt ↗

Primary accession: P08661
Review status: UniProtKB reviewed (Swiss-Prot)
Gene: Mbl2
Protein existence: 1: Evidence at protein level
Organism: Rattus norvegicus (Rat)
Taxonomy ID: 10116
Alternative names: MBP-C
EC number: —
Processing: Precursor
Secondary accessions: —

Protein keywords

Technical term

3D-structureDirect protein sequencingReference proteome

Ligand

CalciumLectinMannose-bindingMetal-binding

Domain

Coiled coilCollagenRepeatSignal

Biological process

Complement activation lectin pathwayComplement pathwayImmunityInnate immunity

PTM

Disulfide bondHydroxylation

Cellular component