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PTEN Antibody

CAT: 0800-R32808Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-R32808Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PTEN is also known as BZS, DEC, CWS1, GLM2, MHAM, TEP1, PTEN1. It is mapped to 10q23.3. This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded by this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. The PTEN structure reveals a phosphatase domain that is similar to protein phosphatases but also has an enlarged active site important for the accommodation of the phosphoinositide substrate.
CAS Number
9007-83-4
Specifications
Western Blot: 0.5-1 µg/mL
UniProt
P60484
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
A recombinant human protein corresponding to amino acids T2-T202 was used as the immunogen for the PTEN antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2.5% BSA, 0.025% sodium azide
Reconstitution
After reconstitution, the PTEN antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This PTEN antibody is available for research use only.
Storage Conditions
After reconstitution, the PTEN antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
Optimal dilution of the PTEN antibody should be determined by the researcher.
Image Legend
Western blot testing of 1) rat brain, 2) mouse liver and 3) human A549 lysate with PTEN antibody at 0.5ug/ml. Predicted molecular weight: 47~55 kDa (isoform 1), 65~70 kDa ('long' isoform) .

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