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ISL1 Antibody / Islet 1

CAT: 0800-R32744Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-R32744Size:100 µg
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Description
Insulin gene enhancer protein ISL-1 is a protein that in humans is encoded by the isl1 gene. This gene encodes a member of the LIM/homeodomain family of transcription factors. The encoded protein binds to the enhancer region of the insulin gene, among others, and may play an important role in regulating insulin gene expression. The encoded protein is central to the development of pancreatic cell lineages and may also be required for motor neuron generation. Mutations in this gene have been associated with maturity-onset diabetes of the young.
CAS Number
9007-83-4
Specifications
Western blot: 0.5-1 µg/mL, Immunohistochemistry (FFPE) : 1-2 µg/mL
UniProt
P61371
Host
Rabbit
Reactivity
Human, Rat
Immunogen
Amino acids 118-161 (DEFALREDGLFCRADHDVVERASLGAGDPLSPLHPARPLQMAAE) from the human protein were used as the immunogen for the ISL1 antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB, IHC-P
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2.5% BSA, 0.025% sodium azide
Reconstitution
After reconstitution, the ISL1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This ISL1 antibody is available for research use only.
Storage Conditions
After reconstitution, the ISL1 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
Optimal dilution of the ISL1 antibody should be determined by the researcher.
Location
Cytoplasmic, nuclear
Image Legend
Western blot testing of 1) rat PC12 and 2) human MCF7 lysate with ISL1 antibody at 0.5ug/ml. Predicted molecular weight ~39 kDa.

UniProtKB · P61371

Insulin gene enhancer protein ISL-1

ISL1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P61371
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
ISL1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
Islet-1
EC number
—
Processing
—
Secondary accessions
P20663, P47894
Protein keywords

Molecular function

ActivatorDevelopmental proteinDNA-binding

Biological process

DifferentiationTranscriptionTranscription regulation

Domain

HomeoboxLIM domainRepeat

Ligand

Metal-bindingZinc

Cellular component

Nucleus

PTM

PhosphoproteinUbl conjugation

Technical term

Proteomics identificationReference proteome

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