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ALDH1A3 Antibody

CAT: 0800-R32728Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-R32728Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Aldehyde dehydrogenase 1 family, member A3, also known as ALDH1A3 or retinaldehyde dehydrogenase 3 (RALDH3), is an enzyme that in humans is encoded by the ALDH1A3 gene. Aldehyde dehydrogenase isozymes are thought to play a major role in the detoxification of aldehydes generated by alcohol metabolism and lipid peroxidation. The enzyme encoded by this gene uses retinal as a substrate, either in a free or a cellular retinol-binding protein form. Mutations in this gene have been associated with microphthalmia, isolated 8, and expression changes have also been detected in tumor cells. Alternative splicing results in multiple transcript variants.
CAS Number
9007-83-4
Specifications
Western blot: 0.5-1 µg/mL, Immunohistochemistry (FFPE) : 2-5 µg/mL, Immunofluorescence: 5 µg/mL, Flow cytometry: 1-3ug/million cells
UniProt
P47895
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Amino acids N37-K154 from the human protein were used as the immunogen for the ALDH1A3 antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB, IHC-P, IF, FACS
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2% Trehalose
Reconstitution
After reconstitution, the ALDH1A3 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This ALDH1A3 antibody is available for research use only.
Storage Conditions
After reconstitution, the ALDH1A3 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
Optimal dilution of the ALDH1A3 antibody should be determined by the researcher.
Image Legend
Western blot testing of 1) rat kidney, 2) mouse stomach and 3) human HepG2 lysate with ALDH1A3 antibody at 0.5ug/ml. Predicted molecular weight ~56 kDa.

UniProtKB · P47895

Retinaldehyde dehydrogenase 3

AL1A3_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P47895
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
ALDH1A3
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
RALDH-3, RalDH3
EC number
1.2.1.36
Processing
—
Secondary accessions
Q6NT64
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

PTM

Acetylation

Cellular component

Cytoplasm

Disease

Disease variantMicrophthalmia

Biological process

Lipid metabolism

Ligand

NAD

Molecular function

Oxidoreductase
Product Datasheet
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