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CHRNA5 Antibody

CAT: 0800-R32708Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-R32708Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Neuronal acetylcholine receptor subunit alpha-5 is a protein that in humans is encoded by the CHRNA5 gene. It is mapped to 15q25.1. The protein encoded by this gene is a nicotinic acetylcholine receptor subunit and a member of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. These receptors are thought to be heteropentamers composed of separate but similar subunits. Defects in this gene have been linked to susceptibility to lung cancer type 2 (LNCR2) .
CAS Number
9007-83-4
Specifications
Western blot: 0.5-1 µg/mL, Immunohistochemistry (FFPE) : 1-2 µg/mL, FACS: 1-3ug/10^6 cells
UniProt
P30532
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Amino acids 44-76 (AKHEDSLLKDLFQDYERWVRPVEHLNDKIKIKF) from the human protein were used as the immunogen for the CHRNA5 antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB, IHC-P, FACS
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2% Trehalose and 0.025% sodium azide
Reconstitution
After reconstitution, the CHRNA5 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This CHRNA5 antibody is available for research use only.
Storage Conditions
After reconstitution, the CHRNA5 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
Optimal dilution of the CHRNA5 antibody should be determined by the researcher.
Location
Cytoplasmic, membranous
Image Legend
Western blot testing of 1) rat skeletal muscle and 2) human HepG2 lysate with CHRNA5 antibody at 0.5ug/ml. Predicted molecular weight ~53 kDa.

UniProtKB · P30532

Neuronal acetylcholine receptor subunit alpha-5

ACHA5_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P30532
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
CHRNA5
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
Precursor
Secondary accessions
Q15824, Q99554
Protein keywords

Cellular component

Cell membraneMembraneSynapse

PTM

Disulfide bondGlycoprotein

Molecular function

Ion channelLigand-gated ion channelReceptor

Biological process

Ion transportTransport

Technical term

Proteomics identificationReference proteome

Domain

SignalTransmembraneTransmembrane helix

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