PRKAR1A Antibody

CAT: 0800-R32679Size: 100 µgDry Ice: NoHazardous: No
CAT#:0800-R32679Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CAMP-dependent protein kinase type I-alpha regulatory subunit is an enzyme that in humans is encoded by the PRKAR1A gene. This protein encoded by this gene was found to be a tissue-specific extinguisher that down-regulates the expression of seven liver genes in hepatoma x fibroblast hybrids. Mutations in this gene cause Carney complex (CNC) . This gene can fuse to the RET protooncogene by gene rearrangement and form the thyroid tumor-specific chimeric oncogene known as PTC2. A nonconventional nuclear localization sequence (NLS) has been found for this protein which suggests a role in DNA replication via the protein serving as a nuclear transport protein for the second subunit of the Replication Factor C (RFC40) . Several alternatively spliced transcript variants encoding two different isoforms have been observed.
CAS Number
9007-83-4
Specifications
Western blot: 0.5-1 µg/mL, IHC (FFPE) : 1-2 µg/mL
UniProt
P10644
Host
Rabbit
Reactivity
Human, Rat
Immunogen
Amino acids E2-E81 from the human protein were used as the immunogen for the PRKAR1A antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB, IHC-P
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2.5% BSA, 0.025% sodium azide
Reconstitution
After reconstitution, the PRKAR1A antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This PRKAR1A antibody is available for research use only.
Storage Conditions
After reconstitution, the PRKAR1A antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
Optimal dilution of the PRKAR1A antibody should be determined by the researcher.
Location
Cytoplasmic, membranous
Image Legend
Western blot testing of 1) rat thymus, 2) human HepG2 and 3) human MCF7 lysate with PRKAR1A antibody at 0.5ug/ml. Predicted molecular weight ~48 kDa.

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