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Thrombospondin Antibody

CAT: 0800-R32670Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-R32670Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
THBS1 is also known as Thrombospondin 1, or TSP1. The protein encoded by this gene is a subunit of a disulfide-linked homotrimeric protein. It is an adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. This protein can bind to fibrinogen, fibronectin, laminin, type V collagen and integrins alpha-V/beta-1. It has been shown to play roles in platelet aggregation, angiogenesis, and tumorigenesis. In addition, the thrombospondin-1 protein is a member of the thrombospondinfamily. It is a multi-domain matrix glycoprotein that has been shown to be a natural inhibitor of neovascularization and tumorigenesis in healthy tissue. Both positive and negative modulation of endothelial cell adhesion, motility, and growth have been attributed to TSP1. This should not be surprising considering that TSP1 interacts with at least 12 cell adhesion receptors, including CD36, aV integrins, b1 integrins, syndecan, and integrin-associated protein (IAP or CD47) . It also interacts with numerous proteases involved in angiogenesis, including plasminogen, urokinase, matrix metalloproteinase, thrombin, cathepsin, and elastase.
CAS Number
9007-83-4
Specifications
Western blot: 0.5-1 µg/mL, ELISA: 0.1-0.5 µg/mL (human protein tested; request BSA-free format for coating)
UniProt
P07996
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Amino acids D27-H112 from the human protein were used as the immunogen for the Thrombospondin antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB, ELISA
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2.5% BSA, 0.025% sodium azide
Reconstitution
After reconstitution, the Thrombospondin antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This Thrombospondin antibody is available for research use only.
Storage Conditions
After reconstitution, the Thrombospondin antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
Optimal dilution of the Thrombospondin antibody should be determined by the researcher.
Image Legend
Western blot testing of 1) rat liver, 2) mouse liver and 3) human HeLa lysate with Thrombospondin antibody. Expected molecular weight ~130/155~200 kDa (unmodified/glycosylated), observed here at 165/180 kDa.

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