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CD212 Antibody / IL12RB1

CAT: 0800-R32618Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-R32618Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
IL12RB1, mapped to 19p13.11, is also known as CD212. The protein encoded by this gene is a type I transmembrane protein that belongs to the hemopoietin receptor superfamily. This protein binds to interleukin 12 (IL12) with a low affinity, and is thought to be a part of IL12 receptor complex. And this protein forms a disulfide-linked oligomer, which is required for its IL12 binding activity. The coexpression of this and IL12RB2 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. Mutations in this gene impair the development of interleukin-17-producing T lymphocytes and result in increased susceptibility to mycobacterial and Salmonella infections. Alternative splicing results in multiple transcript variants.
CAS Number
9007-83-4
Specifications
Western blot: 0.5-1 µg/mL
Gene ID
3594
UniProt
P42701
Host
Rabbit
Reactivity
Human
Immunogen
Amino acids 624-662 (DKGERTEPLEKTELPEGAPELALDTELSLEDGDRCKAKM-human) were used as the immunogen for the IL12RB1 / CD212 antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide
Reconstitution
After reconstitution, the CD212 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This CD212 antibody is available for research use only.
Storage Conditions
After reconstitution, the CD212 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
Optimal dilution of the CD212 antibody should be determined by the researcher.
Image Legend
Western blot testing of human HepG2 cell lysate with CD212 antibody at 0.5ug/ml. Predicted molecular weight: ~73/100 kDa (unmodified/glycosylated) .

UniProtKB · P42701

Interleukin-12 receptor subunit beta-1

I12R1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P42701
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
IL12RB1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
IL-12 receptor subunit beta-1, IL-12R subunit beta-1, IL-12R-beta-1, IL-12RB1
EC number
—
Processing
Precursor
Secondary accessions
A8K308, B2RPF1, B7ZKK3, Q8N6Q7
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Disease

Disease variant

PTM

Disulfide bondGlycoprotein

Cellular component

Membrane

Molecular function

Receptor

Domain

RepeatSignalTransmembraneTransmembrane helix

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